Nikki Glaser made a bit of history the moment she took the stage on Sunday at the 82nd annual Golden Globes, becoming the first female solo host of the televised ceremony.

Glaser, also a nominee this year for her second HBO stand-up comedy special, Someday You’ll Die, has been on a professional roll, turbo-charged by her viral performance at the Netflix roast of Tom Brady in May. The comic referred to the reaction to that experience as “life-changing,” telling ABC’s Jimmy Kimmel in December, “The next day, I was in line places and seeing my face on people’s phones.”

In her opening monologue, Glaser wasted no time testing how willing attendees were to laugh at themselves, referring to the Globes as “Ozempic’s biggest night,” referencing the popular weight-loss drug.

Noting that the room was filled with powerful and famous people, Glaser joked, “You could really do anything. Except tell the country who to vote for.” 

Glaser also skewered the “Joker” sequel (noting that they weren’t represented), noted the number of movie stars appear in TV shows and said the real goal of acting was launching tequila brands that would make stars rich enough that they never needed to act again.

Proclaimed “The new queen of comedy” by the Hollywood Reporter in the wake of the Brady roast, Glaser’s take-no-prisoners style has evoked comparisons to another Globes host, five-timer Ricky Gervais, whose occasionally brutal takedowns of those in the audience produced some uncomfortable moments as well as hilarious ones.

A veteran of the roast circuit, Glaser’s edgy brand of comedy could be seen in her most recent special, which among other things explored issues of fertility and her lack of interest in having children, in contrast to some of her friends.

Although Glaser is a solo standout, Saturday Night Live alumni Tina Fey and Amy Poehler co-hosted the Globes four times — from 2013 to 2015, and again in 2021.

Unlike most awards telecasts, the Globes ceremony has actually been conducted host-free for most of its history, and although various performers helped preside over the event during the 1980s, didn’t officially have hosts until 1995, when John Larroquette and Janine Turner shared those duties.

The show didn’t have a designated emcee again until 2010, when Gervais began his run. Others to host in recent years include NBC late-night stars Jimmy Fallon and Seth Meyers, Andy Samberg and Sandra Oh, and comics Jerrod Carmichael and Jo Koy.